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KMID : 1189420080210010055
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Journal of Korean Oriental Medical Ophthalmology & Otolaryngology & Dermatology
2008 Volume.21 No. 1 p.55 ~ p.69
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Effects of Gleditsia spina (GS) water extract on Gene Expression of Human Melanoma cells, by using Microarry technique
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Park Yong-Ho
Kim Jong-Han
Park Su-Yeon
Choi Jung-Hwa
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Abstract
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Objective: This study was designed to investigated effects of Gleditsia spina (GS) on human derived melanoma cells
Methods: The genetic profile for the effect of medicine on human derived melanoma cells of SK-MEL-2, was measured by using microarray technique, and the functional analysis on these genes was conducted. The network of total protein interactions was measured by using cytoscape program.
Results: Total 253 genes were up-regulated and 439 genes down-regulated in cells treated with GS. Genes induced or suppressed by GS were all mainly concerned with metabolic process, regulation of biological process and protein binding.
Conclusion: Suggest the possibility of GS as anti-cancer drug and cosmetic agent, and also suggest that related mechanisms are involved in regulation of intra-cellular metabolism in melanoma cells.
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KEYWORD
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Gleditsiaspina(GS)
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